Protein name:
Protein Mdm4 ;
Alternative:
Mdm2-like p53-binding protein ;Double minute 4 protein ;p53-binding protein Mdm4 ;Protein Mdmx ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with MDM2, TP53, TP73 and USP2. Found in a trimeric complex with UPB2, MDM2 and MDM4.
Function:
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MTSFSTSAQC | STSDSACRIS | PGQINQVRPK | LPLLKILHAA | GAQGEMFTVK |
100:
EVMHYLGQYI | MVKQLYDQQE | QHMVYCGGDL | LGELLGRQSF | SVKDPSPLYD |
150:
MLRKNLVTLA | TATTDAAQTL | ALAQDHSMDI | PSQDQLKQSA | EESSTSRKRT |
200:
TEDDIPTLPT | SEHKCIHSRE | DEDLIENLAQ | DETSRLDLGF | EEWDVAGLPW |
250:
WFLGNLRSNY | TPRSNGSTDL | QTNQDVGTAI | VSDTTDDLWF | LNESVSEQLG |
300:
VGIKVEAADT | EQTSEEVGKV | SDKKVIEVGK | NDDLEDSKSL | SDDTDVEVTS |
350:
EDEWQCTECK | KFNSPSKRYC | FRCWALRKDW | YSDCSKLTHS | LSTSDITAIP |
400:
EKENEGNDVP | DCRRTISAPV | VRPKDAYIKK | ENSKLFDPCN | SVEFLDLAHS |
450:
SESQETISSM | GEQLDNLSEQ | RTDTENMEDC | QNLLKPCSLC | EKRPRDGNII |
490:
HGRTGHLVTC | FHCARRLKKA | GASCPICKKE | IQLVIKVFIA |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Bovine
ELISA Kit for Human Protein Mdm4
ELISA Kit for Human Protein Mdm4
ELISA Kit for Human Protein Mdm4
ELISA Kit for Human Protein Mdm4
CLIA Kit for Human Protein Mdm4
CLIA Kit for Human Protein Mdm4
CLIA Kit for Human Protein Mdm4
CLIA Kit for Human Protein Mdm4
Polyclonal Antibody for Human Protein Mdm4
Polyclonal Antibody for Human Protein Mdm4
Polyclonal Antibody for Human Protein Mdm4
Polyclonal Antibody for Human Protein Mdm4
Monoclonal Antibody for Human Protein Mdm4
Monoclonal Antibody for Human Protein Mdm4
Monoclonal Antibody for Human Protein Mdm4
Monoclonal Antibody for Human Protein Mdm4
Protein for Human Protein Mdm4
Protein for Human Protein Mdm4
Protein for Human Protein Mdm4
Protein for Human Protein Mdm4
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Isolation and identification of the human homolog of a new p53-binding protein, Mdmx."
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PubMed ]
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Colon tumor .
2.
"Identification of an aberrantly spliced form of HDMX in human tumors: a new mechanism for HDM2 stabilization."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM HDMX211)
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Gastric mucosa .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS THR-175 AND ILE-406
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"The DNA sequence and biological annotation of human chromosome 1."
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more...
Nature441:315-321(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5)
tissue :
Brain .
tissue :
Testis .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING (ISOFORMS 2 AND 3)
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : MUTAGENESIS OF CYS-437
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN TP53 ACTIVATION;PHOSPHORYLATION AT SER-342 AND SER-367 BY CHEK2;UBIQUITINATION;INTERACTION WITH MDM2
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN TP53 ACTIVATION;PHOSPHORYLATION AT SER-367 BY CHEK1;INTERACTION WITH YWHAG
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH USP2 AND MDM2;INDUCTION;UBIQUITINATION;DEUBIQUITINATION BY USP2
12.
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Proteomics2:212-223(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : MASS SPECTROMETRY
tissue :
Mammary cancer .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 300-340