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Index > Protein center > MDM4(Gene name) > Human
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  • MDM4 (Gene name),
  • Protein Mdm4 (Protein name ),  MDM4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MDM4(MDMX);
    Protein name:
    Protein Mdm4;
    Alternative:
    Mdm2-like p53-binding protein;Double minute 4 protein;p53-binding protein Mdm4;Protein Mdmx;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with MDM2, TP53, TP73 and USP2. Found in a trimeric complex with UPB2, MDM2 and MDM4.
    Function:
    Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    490
    Sequence:
    50:
    MTSFSTSAQC | STSDSACRIS | PGQINQVRPK | LPLLKILHAA | GAQGEMFTVK | 
    100:
    EVMHYLGQYI | MVKQLYDQQE | QHMVYCGGDL | LGELLGRQSF | SVKDPSPLYD | 
    150:
    MLRKNLVTLA | TATTDAAQTL | ALAQDHSMDI | PSQDQLKQSA | EESSTSRKRT | 
    200:
    TEDDIPTLPT | SEHKCIHSRE | DEDLIENLAQ | DETSRLDLGF | EEWDVAGLPW | 
    250:
    WFLGNLRSNY | TPRSNGSTDL | QTNQDVGTAI | VSDTTDDLWF | LNESVSEQLG | 
    300:
    VGIKVEAADT | EQTSEEVGKV | SDKKVIEVGK | NDDLEDSKSL | SDDTDVEVTS | 
    350:
    EDEWQCTECK | KFNSPSKRYC | FRCWALRKDW | YSDCSKLTHS | LSTSDITAIP | 
    400:
    EKENEGNDVP | DCRRTISAPV | VRPKDAYIKK | ENSKLFDPCN | SVEFLDLAHS | 
    450:
    SESQETISSM | GEQLDNLSEQ | RTDTENMEDC | QNLLKPCSLC | EKRPRDGNII | 
    490:
    HGRTGHLVTC | FHCARRLKKA | GASCPICKKE | IQLVIKVFIA | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    UniGene:
    String:
    MIM:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Protein Mdm4
    Cat.:
    E12870h
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    96T
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    ELISA Kit for Human Protein Mdm4
    Cat.:
    E12870m
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    Packing:
    96T
    ELISA Kit for Human Protein Mdm4
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    E12870r
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    96T
    ELISA Kit for Human Protein Mdm4
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    E12870b
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    Packing:
    96T
    CLIA Kit for Human Protein Mdm4
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    U12870m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Protein Mdm4
    Cat.:
    U12870b
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    Packing:
    96T
    CLIA Kit for Human Protein Mdm4
    Cat.:
    U12870h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Protein Mdm4
    Cat.:
    U12870r
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Protein Mdm4
    Polyclonal Antibody for Human Protein Mdm4
    Cat.:
    P12870Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Protein Mdm4
    Cat.:
    P12870Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Protein Mdm4
    Cat.:
    P12870Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Protein Mdm4
    Monoclonal Antibody for Human Protein Mdm4
    Monoclonal Antibody for Human Protein Mdm4
    Monoclonal Antibody for Human Protein Mdm4
    Protein for Human Protein Mdm4
    Protein for Human Protein Mdm4
    Protein for Human Protein Mdm4
    Protein for Human Protein Mdm4

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    References
    1. 1.
      "Isolation and identification of the human homolog of a new p53-binding protein, Mdmx."
      Shvarts A. , Bazuine M. , Dekker P. , Ramos Y.F.M. , Steegenga W.T. , Merckx G. , van Ham R.C.A. , van der Houven van Oordt W. , van der Eb A.J. , Jochemsen A.G.
      Genomics43:34-42(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Colon tumor.
    2. 2.
      "Identification of an aberrantly spliced form of HDMX in human tumors: a new mechanism for HDM2 stabilization."
      Giglio S. , Mancini F. , Gentiletti F. , Sparaco G. , Felicioni L. , Barassi F. , Martella C. , Prodosmo A. , Iacovelli S. , Buttitta F. , Farsetti A. , Soddu S. , Marchetti A. , Sacchi A. , Pontecorvi A. , Moretti F.
      Cancer Res.65:9687-9694(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM HDMX211)
    3. 3.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Gastric mucosa.
    4. 4.
      NIEHS SNPs program
      Submitted (2002-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS THR-175 AND ILE-406
    5. 5.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5)
      tissue: Brain.
      tissue: Testis.
    7. 7.
      "Identification of a domain within MDMX-S that is responsible for its high affinity interaction with p53 and high-level expression in mammalian cells."
      Rallapalli R. , Strachan G. , Tuan R.S. , Hall D.J.
      J. Cell. Biochem.89:563-575(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORMS 2 AND 3)
    8. 8.
      "Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein."
      Sharp D.A. , Kratowicz S.A. , Sank M.J. , George D.L.
      J. Biol. Chem.274:38189-38196(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF CYS-437
    9. 9.
      "ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage."
      Chen L. , Gilkes D.M. , Pan Y. , Lane W.S. , Chen J.
      EMBO J.24:3411-3422(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TP53 ACTIVATION;PHOSPHORYLATION AT SER-342 AND SER-367 BY CHEK2;UBIQUITINATION;INTERACTION WITH MDM2
    10. 10.
      "14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation."
      Jin Y. , Dai M.S. , Lu S.Z. , Xu Y. , Luo Z. , Zhao Y. , Lu H.
      EMBO J.25:1207-1218(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TP53 ACTIVATION;PHOSPHORYLATION AT SER-367 BY CHEK1;INTERACTION WITH YWHAG
    11. 11.
      "MdmX is a substrate for the deubiquitinating enzyme USP2a."
      Allende-Vega N. , Sparks A. , Lane D.P. , Saville M.K.
      Oncogene29:432-441(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH USP2 AND MDM2;INDUCTION;UBIQUITINATION;DEUBIQUITINATION BY USP2
    12. 12.
      "Cluster analysis of an extensive human breast cancer cell line protein expression map database."
      Harris R.A. , Yang A. , Stein R.C. , Lucy K. , Brusten L. , Herath A. , Parekh R. , Waterfield M.D. , O'Hare M.J. , Neville M.A. , Page M.J. , Zvelebil M.J.
      Proteomics2:212-223(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MASS SPECTROMETRY
      tissue: Mammary cancer.
    13. 13.
      "Solution structure of the ZF-RANBP domain of p53-binding protein MDM4."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2005-11) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 300-340
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